When the Query Engineering Inc. / Sigma Seven Systems Ltd. XLerators were designed, Lisa users/purchasers were almost exclusively interested in using MacWorks Plus/II to run Macintosh applications. As a result, these accelerators were not designed to be used with the Lisa Office System and Programmer's Workshop.
The Lisa Office System uses the custom MMU design in the Lisa, which makes an accelerator design more challenging.
Now that FPGAs have become more affordable, along with the advent of "68000 core" designs (FX68K & TG68K) that can be implemented in an FPGA, I think the possibility of an accelerator that works in LOS is now a practical project.
My current thought is that this would involve a new CPU board, with the 68000 and MMU implemented in the FPGA, along with possibly all of the other CPU board logic, and with main memory on the same board to avoid the slot memory speed bottleneck. Perhaps the 32k of video memory would be separate to minimize the potential slow-down from sharing memory. Features to integrate software debugging would also be very beneficial as using a logic analyzer with the Lisa's 68k is limited without major equipment.
The potential for additional high speed hardware is there as well, such as a fast parallel port that (with a modified driver) might reach the limits of the DMA designs of the Apple ProFile and Patrick's IDEfile.
I see a post at
www.atari-forum.com that describes the TG68K core running in an FPGA at 32MHz as being significantly faster than a real 68000 at 40 MHz. LOS running 10 times faster would be nice.
However, maybe such a project is of little interest with an equivalent or better emulator?