The weather has turned and some free time allowed me to verify the state of LisaEm compilation on macOS.
As it stands now, the 'master' branch of LisaEm is successfully compiling on both arm64 and x86_64 builds of macOS 13.6 (Ventura) w/ the latest wxWidgets 3.2.3. Will be upgrading to Sonoma later and will verify compatibility there.
I am not sure how sustainable maintaining compatibility across multiple CPU architectures and legacy and modern operating systems will be moving forward. I'm targeting recent-ish builds of macOS and Linux, and possibly Windows 10, and may remove support for PowerPC and older MacOS X releases as time goes by. I'd really like to fix the crash on close experienced in macOS, and possibly automate the ROM split functions to work around rom-less mode bugs.
For those interested, recent changes have been pushed here:
https://github.com/arcanebyte/lisaem