I've been experimenting with various combinations of hardware and software to enable 
BLU's built-in serial communication / file transfer capability between Lisa and modern Mac hardware, like a MacBook Pro. So far, I have been successful with the Lisa 2/10 across the following configurations:
System #1:
   Late 2013 13” MacBook Pro (Intel, macOS Big Sur 11.7.10)
Software:   
CoolTerm. 
Lisa is connected to:   
C2G 6’ DB25 Male to DB9 Female Serial RS232 Null Modem Cable.    
Gearmo USB to Serial RS-232 Adapter with LED Indicators, FTDI chip    or   
Sabrent CB-DB9P USB 2.0 To Serial DB9 Male (9 Pin) RS232 Cable Adapter, Prolific chip Note: Flow Control = DTR on, CTS off. 
System #2:
   Late 2020 13” MacBook Pro (Apple Silicon, macOS Sequoia 15.1.1)
Software:   
CoolTerm.
Lisa connected via:   
C2G 6’ DB25 Male to DB9 Female Serial RS232 Null Modem Cable   Sabrent CB-DB9P USB 2.0 To Serial DB9 Male (9 Pin) RS232 Cable Adapter, Prolific chip   USB-A to USB-C adapterNote: Flow Control = DTR on, CTS off.
I have also been experimenting with another macOS app called 
Serial and text communication seems to be working, but file transfers do not. I have asked the developer for more information.
I have not yet found a working combination for Lisa 1/5 machines, but I am working on that also. Seems to be related to pin 4 (RTS) where the Lisa 2/10 features a 10k pull-up resistor and the Lisa 1/5 does not, or null modem wiring (TBC).
Hopefully this info helps someone with a Lisa 2/10 (or Mac XL) that wants to use 
BLU's built-in serial communication capability. Special thanks to 
sigma7 for creating that software, and for continuously providing his insight while I continue looking for solutions.
For reference, here's a screenshot of CoolTerm's working serial port configuration:
