Perhaps the biggest annoyance I've encountered when using ESProFile is the fact that you have to use a ribbon cable to convert the onboard 26-pin IDC connector to DB25 whenever plugging it into a Lisa 1, 2/5, or a parallel card, as opposed to a Widget connector. I didn't have room on the ESProFile board for both connectors, so I chose the one that seemed like it would be the most universal. I think I made the right choice, but it's still annoying.
But the other day, @Lisa1 sent me this handy adapter board that converts from IDC to DB25 without needing a ribbon cable. The IDC socket is even positioned so that the ESProFile board is aligned with the edges of the adapter; a really nice touch!
Maybe I'll design one of these and stick it in the ESProFile GitHub repo whenever I get around to designing Rev. 2 of the hardware if anybody's interested...