LisaList2

I and a number of other people I have worked with successfully use LisaCom with Windows over USB-Serial.

For connecting a Lisa to a Windows PC over serial (LISACom, or any
terminal work), the USB-to-serial adapter matters:

Get one with an FTDI chipset (FT232RL). Avoid the Prolific PL2303
adapters: many are counterfeit chips, and the current Windows driver
refuses to work with them.

It must be a true RS-232 adapter with a DB9 connector, not a USB-TTL
board. A real Lisa drives full RS-232 voltages, and a TTL-level
board will not talk to it and could be damaged.

The one I use is the CableCreation USB to RS-232 (FTDI, DB9 male).
DTECH also sells an FT232RL version. Either is about $15.

The full chain on my Lisa 2/10:

  PC USB port
  -> FTDI USB-to-serial adapter (DB9 male)
  -> DB9 female to DB25 male adapter (straight-through)
  -> DB25 serial cable
  -> null modem adapter
  -> Lisa Serial B (DB25 female on the back of the Lisa)

The Lisa and the PC are both wired as terminals, so the transmit and
receive lines have to cross exactly once. That is the null modem's
job. Use only one crossover in the chain: a null-modem cable plus a
null-modem adapter cancel each other out and nothing gets through.

On the PC side I use Tera Term at 9600 baud, 8 data bits, no parity,
1 stop bit. The adapter shows up as "USB Serial Port" on a COM port.

Quick test of the adapter by itself: short pins 2 and 3 on its DB9
with a paperclip and type in Tera Term. If your typing echoes back,
the adapter and driver are working.

dmac1267's  problem is not in LisaCOM, but in the LisaEm emulator. It does not support Windows well when it comes to serial port data transfer, and, in fact, it seems that the "Serial" option (setup port B to connect to a serial port on the host PC) in the LisaEm preferences has been disabled (unavailable) due to that.