With the source code for the operating system, a minimal-hardware alternative would be to modify the Lisa OS to handle bigger hard disks. ProFile emulators can go bigger than just 5 or 10 MiB --- Cameo/Aphid for example can do hundreds of megabytes.
That's a good point! It looks like the Cameo/Aphid, X/ProFile, ArduinoFile, and IDEFile all support volumes larger than 10MB, so we might want to give that a try before going to the trouble to emulate the DataTower.
Keep in mind, there may be hard limits not just in the ProFile driver, but also in the Lisa File System itself that will prevent very large volumes.
I don't remember the size off the top of my head, but barely remember articles about the DataTower saying that it didn't put up one large volume, but rather something like 4. Since the size is 80MB, that's likely the unformatted size, so more likely 64MB is useable, and divided by 4 that might set the limit to 16MB/vol? I'm just guessing here, I don't have a DataTower, so could be totally wrong.
This might have been for an earlier version of LOS as well, so, no idea really. We'll know when it's implemented, I suppose.